MicroRNA Gene Regulatory Network Biomarker Analysis in Prostate Cancer
Keywords:
prostate cancer, microRNA, gene regulatory network, biomarker, bioinformaticsAbstract
Cancer is one of the cardinal causes of mortality in humans. The mutation is the one who is responsible for the change of gene function and activity that cause disease like cancer. Comprehension on gene regulatory network is a feasible approach to understand the complexity of biology and unrevealing the reconnection between genes and what it is responsible for. This paper discusses prostate cancer analysis using the microRNA gene regulatory network to understand the interaction and function of the gene responsible. MicroRNA are extensively regulated gene expression with the strong inclination as biomarkers for cancer diagnosis, prognosis, and therapy. Some possible candidates for microRNA prostate cancer biomarker are miR-145-5p, miR-204-5p, and miR-648. However further analysis and technologies is needed to reduce the conflict between each data.
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